IDSA Recommended Dosages of Antimicrobial Agents Administered by the Intraventricular Route Amikacin - 5–50 mg Amphotericin B - 0.01–0.5 mg in 2 mL of 5% dextrose inwater Colistin - 10 mg Daptomycin - 2–5 mg Gentamicin - 1–8 mg Polymyxin B - 5 mg Quinupristin/dalfopristin - 2–5 mg Tobramycin - 5–20 mg Vancomycin - 5–20 mg Dosage recommendations in adults based on ventricle size/volume as follows: • Slit ventricles: 5 mg vancomycin and 2 mg gentamicin • Normal size: 10 mg vancomycin and 3 mg gentamicin • Enlarged ventricles: 15–20 mg vancomycin and 4–5 mg gentamicin. Recommendations for frequency of administration based on external ventricular drain output over 24 hours as follows: • <50 mL/24 hours: every third day • 50–100 mL/24 hours: every second day • 100–150 mL/24 hours: once daily • 150–200 mL/24 hours: increase the dosage by 5 mg of vancomycin and 1 mg of gentamicin and give once daily • 200–250 mL/24 hours: increase the dosage by 10 mg of vancomycin and 2 mg of gentamicin and give once daily. #Intraventricular #antibiotics #dosing #pharmacology #ventriculitis #table #idsa
