IDSA - Antimicrobial Regimens for Acute Bacterial Rhinosinusitis in Children Initial empirical therapy • Amoxicillin-clavulanate (45 mg/kg/day PO bid) Beta-lactam allergy Type I hypersensitivity • Levofloxacin (10–20 mg/kg/day PO every 12–24 h) Beta-lactam allergy Non–type I hypersensitivity • Clindamycina (30–40 mg/kg/day PO tid) plus cefixime (8 mg/kg/day PO bid) or cefpodoxime (10 mg/kg/day PO bid) Risk for antibiotic resistance or failed initial therapy • Amoxicillin-clavulanate (90 mg/kg/day PO bid) • Clindamycina (30–40 mg/kg/day PO tid) plus cefixime (8 mg/kg/day PO bid) or cefpodoxime (10 mg/kg/day PO bid) • Levofloxacin (10–20 mg/kg/day PO every 12–24 h) Severe infection requiring hospitalization • Ampicillin/sulbactam (200–400 mg/kg/day IV every 6 h) • Ceftriaxone (50 mg/kg/day IV every 12 h) • Cefotaxime (100–200 mg/kg/day IV every 6 h) • Levofloxacin (10–20 mg/kg/day IV every 12–24 h) #Antimicrobial #Antibiotics #Bacterial #Rhinosinusitis #IDSA #peds #pediatrics #management
