Antimicrobial Regimens for Acute Bacterial Rhinosinusitis in Adults Initial empirical therapy: • Amoxicillin-clavulanate (500 mg/125 mg PO tid, or 875 mg/125 mg PO bid) • Doxycycline (100 mg PO bid or 200 mg PO qd) Beta-lactam allergy: • Doxycycline (100 mg PO bid or 200 mg PO qd) • Levofloxacin (500 mg PO qd) • Moxifloxacin (400 mg PO qd) Risk for antibiotic resistance or failed initial therapy: • Amoxicillin-clavulanate (2000 mg/125 mg PO bid) • Levofloxacin (500 mg PO qd) • Moxifloxacin (400 mg PO qd) Severe infection requiring hospitalization: • Ampicillin-sulbactam (1.5–3 g IV every 6 h) • Levofloxacin (500 mg PO or IV qd) • Moxifloxacin (400 mg PO or IV qd) • Ceftriaxone (1–2 g IV every 12–24 h) • Cefotaxime (2 g IV every 4–6 h) #Antimicrobial #empiric #idsa #antibiotics #Bacterial #Rhinosinusitis #Adults #management #pharmacology
