Select Antiretroviral and Non–Rifamycin-based Antituberculosis Drug Overlapping Toxicities and Potential Adverse Drug–Drug Interactions • Arrhythmias, QT interval prolongation - Fluoroquinolones, bedaquiline, delamanid, clofazimine • Hepatic cytochrome P450 enzyme system metabolism - Bedaquiline, delamanid • Nephrotoxicity - Aminoglycosides, capreomycin • Mental health changes (depression, psychosis, dizziness, etc.) - Cycloserine, isoniazid, ethionamide, fluoroquinolones • Peripheral neuropathy - Aminoglycosides, capreomycin, linezolid, isoniazid, ethionamide, cycloserine, fluoroquinolones • Hepatotoxicity - Isoniazid, pyrazinamide, ethionamide, p-aminosalicylic acid, clofazimine • Skin rash - All TB drugs, Note skin pigmentation with clofazimine use. Thioacetazone should be avoided in people with HIV, because of an elevated risk of a severe adverse skin reaction • Dysglycemia - Ethionamide, p-aminosalicylic acid, fluoroquinolones, linezolid • Myelosuppression/cytopenias - Linezolid • Lactic acidosis - Linezolid #Antituberculosis #Drug #toxicities #adverseeffects #sideeffects #interactions #pharmacology
