IDSA Recommendations for Preventing and Treating Cryptococcosis in HIV-AIDS Treatment for cryptococcosis consists of 3 phases: induction, consolidation, and maintenance therapy Induction Therapy (For At Least 2 Weeks, Followed by Consolidation Therapy) - Preferred Regimens: • Liposomal amphotericin B 3–4 mg/kg IV daily plus flucytosine 25 mg/kg PO QID (AI); or • Amphotericin B deoxycholate 0.7–1.0 mg/kg IV daily plus flucytosine 25 mg/kg PO QID (AI)—if cost is an issue and the risk of renal dysfunction is low Consolidation Therapy (For At Least 8 Weeks, Followed by Maintenance Therapy) • To begin after at least 2 weeks of successful induction therapy (defined as substantial clinical improvement and a negative CSF culture after repeat LP) Preferred Regimen: • Fluconazole 400 mg PO or IV once daily Maintenance Therapy - Preferred Regimen: • Fluconazole 200 mg PO for at least 1 year (AI)—see below for recommendation of when to stop maintenance therapy #Cryptococcosis #Cryptococcus #IDSA #Prevention #Treatment #management #opportunistic #infections #HIVAIDS #pharmacology
