IDSA Recommendations for Treating Coccidiodomycosis in HIV-AIDS Treating Mild Infections (Such As Focal Pneumonia or asymptomatic patients with positive serology and CD4 count <250 cells/mm3) - Preferred Therapy: • Fluconazole 400 mg PO once daily (BII)*, or • Itraconazole 200 mg PO twice daily (BII)* Treating Bone or Joint Infections - Preferred Therapy: • Itraconazole 200 mg PO twice daily Treating Severe, Non-Meningeal Infection (Diffuse Pulmonary or Severely Ill Patients with Extrathoracic Disseminated Disease)—Acute Phase - Preferred Therapy: • Lipid formulation amphotericin B 3–5 mg/kg IV daily (AIII), or • Amphotericin B deoxycholate 0.7–1.0 mg/kg IV daily (AII) • Use until clinical improvement, then switch to triazole (BIII) #Coccidiodomycosis #IDSA #Prevention #Treatment #management #opportunistic #infections #HIVAIDS #pharmacology
