Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated with more severe disease & renal involvement • Used to monitor disease activity Anti-Ro/SSA - 40% • Associated with skin manifestations • Neonatal SLE, including congenital heart block • Sjogren syndrome Anti-UI-ribonucleoprotein - 35% • Raynaud phenomenon & esophageal dysmotility • MCTD (SLE/systemic sclerosis/polymyositis overlap syndrome) Anti-Smith - 25% • Specific for SLE. Associated with more severe disease Treatment: • Mild disease- Hydroxychloroquine • Moderate disease - Hydroxychloroquine *Short course of steroids +/- methotrexate or azathioprine • Severe disease- high dose steroid+ mycophenolate, azathioprine, cyclophosphamide or rituximab Dr. Ann Marie Kumfer @AnnKumfer #Systemic #Lupus #Erythematosus #SLE #Summary #diagnosis #rheumatology #management
