Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm Idiopathic Interstitial Pneumonia • (UIP) Usual Interstitial Pneumonia - fibrosis, with relatively little inflammation, most common • (NSIP) Non-specific Interstitial Pneumonia • (DIP) Desquamative Intersitial Pneumonia • (LIP) Lymphoid Interstitial Pneumonia - slowly progressive dyspnea and cough, “velcro” crackles, clubbing, worse at the bases and periphery, Poor Prognosis Granulomatous - Sarcoidosis (Debate if this should be 1° or 2°) - Multisystem characterized by granulomatous inflammation Primary - Other (Rare) • Lymphangioleiomyomatosis (LAM), • Pulmonary Langerhans cell histiocytosis (PLCH) • Eosinophilic pneumonia Congestive Heart Failure - Impaired cardiac function resulting in fluid leaking out of pulmonary capillaries into intersitial space Infection - “Atypical” Pneumonia Malignancy - Metastases to lung as nodules Hypersensitivity Pneumonia - Immunologic (hypersensitivity) reaction to inhaled antigen Connective Tissue Disease - Rheumatoid Arthritis, Systemic Lupus and Scleroderma Pneumonconiosis - Lung disease (nonneoplastic) resulting from inhalation of inorganic and organic dusts Drugs/Radiaition • Drugs: Amiodarone, Nitrofurantoin, Methotrexate, Beomycin • Acute or Chronic Radiation Pneumonitis - 4-12 weeks after exposure, 6-12 after. - Amy Chung, MD, MSc @AmyChung #Interstitial #Lung #Diseases #ILD #Causes #Differential #Diagnosis #Algorithm
