Blood Disorders - Markers and Differential Diagnosis Algorithm
Acute
• Myloid (AML) - CD13, CD33, CD34, HLA-DR, MPO, Sudan Black, Auer rod
• Lymphoid (ALL) - PAS, TdT Lymphadenopathy, CNS Involvement
- B-cell - CD19, CD22, CD10
- T-cell - CD7, CD3
Chronic
• Myloid Disorders
- Myelodysplastic Disorder - Abnormal morphology, Pseudo Pelger-Huet, Macrocytic anemia
- Myeloproliferation Disorder - Abnormal Proliferation
• Lymphoid (CLL) - CD38(new), Light chain restriction (κ or λ), Smudge Cells
- B-cell CD5, CD19, CD20, CD23,
o CML - bcr-able (+) ↑ WBC
o Other bcr-able (-) - Polycythemia Vera (PV), Essential Thrombocytosis (ET), Myelofibrosis (MF), Reactive Thrombocytosis
- T-cell
- Amy Chung, MD, MSc @AmyChung
#Blood #Disorders #hematology #Markers #Differential #Diagnosis #Algorithm
