Central Nervous System Pharmacology - Somatic and Autonomic Receptors Somatic • Rocuronium -> Non-depolarizing (reversible competitive inhibitors) • Succinylcholine -> Depolarization • Neostigmine - blocks action AchE = increases the levels of Ach (reversal of nondepolarizing agents) • Atropine -> reversible competitive antagonist (anti- cholinergic) Autonomic • Parasympathetic “Rest and Digest” - Ach -> Nicotinic Receptor -> Ach -> Muscarinic Receptor • Sympathetic “Fight or Flight” - Ach -> Nicotinic Receptor -> NE -> Adrenergic Receptor • Sympathetic Innervation of Adrenal Medulla - Ach -> Adrenal Medulla Nicotinic Receptor -> Epinephrine released into blood -> Adrenergic Receptor - Amy Chung, MD, MSc @AmyChung #Central #NervousSystem #CNS #Somatic #Autonomic #Receptors #Pharmacology
