Oral Hypoglycemics in Diabetes Management
1 INSULIN SENSITIZER
• TZD
- PPAR gamma agonist
- “_glitazone” - Pioglitaxone (Actos), Rosiglitaxone (Avandia)
• Biguanides
- Inhibit gluconeogenesis, Also ↑ Sensitivity
- Metformin (Glucophage)
2 INSULIN SECRETAGOGUES
• Meglitinides
- Stimulate β cells to secrete
- Repaglinide (GlucoNorm)
• Sulfonylureas
- ↑ β-cells secretion
- Gliclazide (Diamicron), Glimepiride (Amaryl), Glyburide (Diabeta)
3 CARB ABSORPTION INHIBITOR
• alpha-glucosidase inhibitor
- Prevents polysaccharide degradation, slows gut starch absorption
- Acarbose (Prandase)
• SGLT-2
- Inhibit proximal tubule glucose reabsorption
- Canagliflozin (Invokana)
4 INCRETIN AGENTS
• GLP-1 agonists
- Inhibit gastric emptying…↑ insulin secretion
- Dulaglutide (Trulicity), Exenatide (Byetta), Exenatide QW (Bydureon), Liraglutide (Victroza), Lixisenatide (Adlyxin)
• DPP-4 Inhibitors
- Prevents GLP breakdown by inhibiting DPP-4 ENZ
- “__gliptin” - Sitagliptin (Januvia), Linogliptin (Trajenta)
- Amy Chung, MD, MSc @AmyChung
#Oral #Hypoglycemics #Diabetes #Management #pharmacology #DM2 #DMII #Classification
