Hypercalcemia - Hormones and Pathophysiology Calcitriol: • Bones: Enhances mineralization • GI Tract: ↑ Ca2+ absorption, ↑ PO4- absorption • Kidneys: ↑ Ca2+ reabsorption, ↑ PO4- reabsorption • Serum: ↑ Ca2+, ↑ PO4- PTH: • Bones: ↑ Bone resorption (↑ Ca2+ and ↑ PO4- release) • Kidneys: ↑ Ca2+ reabsorption, ↓ PO4- reabsorption • Serum: ↑ Ca2+, ↓ PO4- Calcitonin: • Bones: ↓ Bone resorption (↓ Ca2+ and ↑ PO4- release) • GI Tract: ↓ Ca2+ absorption • Kidneys: ↑ Ca2+ reabsorption, PO4- reabsorption • Serum: ↓ Ca2+, ↓ PO4- #Hypercalcemia #Hormones #Pathophysiology #endocrinology
