Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian cancer, pancreatic cancer, thymoma, Rhabdomyosarcoma, papillary adenocarcinoma of thyroid Vitamin D mediated 1,25 - dihydroxyvitamin D - Increased renal and intestinal calcium absorption and stimulates resorption in the bone • Lymphomas PTHrp Mediated - Stimulate calcium reabsorption in kidney, Stimulates resorption in the bone • Squamous Cell of lung, Renal Cell, Breast Cancer, HTLV-I lymphoma - Dr. Kenar Jhaveri @kdjhaveri #Hypercalcemia #Malignancy #Pathophysiology #Differential #Diagnosis #algorithm
