NSAIDS and their effects on the Kidney - Pathophysiology Arachidonic Acid metabolites into alternative pathways that modify immune function • Minimal Change Disease via Prostaglandin inhibition • Increase Na reabsorption in Proximal, loop and distal component of Nephron: CHF, HTN, Edema • Inhibition of Renin release: hyporenin hypoaldo, hyperkalemic distal RTA • Increase H2O absorption in distal nephron: Hyponatremia • Vasoconstriction and decreased renal blood flow: Pre renal AKI Idiosyncratic immune reaction • Acute Interstitial Nephritis Necrosis of kidney tissue • Papillary Necrosis Dr. Kenar Jhaveri @kdjhaveri #NSAIDS #KidneyDisease #nephrology #Effects #pathophysiology #renal
