Persistent UC Symptoms Despite 5-ASA Therapies
• Assess for Drug Adherence
• Disease Activity Assessment (bloody diarrhea correlates w active UC > non-bloody diarrhea)
• FCP, CRP, Colonoscopy
• Rule-Out Infection, Cdiff
Mild Colitis
• Optimize 5-ASA PO/PR
• Add CAMs (curcumin, probiotic)/Dietary Tx
• Evaluate for Alternative
• Observation (FCP/CRP/Scope)
• Steroid Course
• ? Escalate Treatment
Mod/Severe Colitis
Escalate Treatment:
• Steroid Course *
• Maintenance options:
- Thiopurines
- Anti-TNF
- Anti-lntegrin
- Anti-IL12/lL23
- JAK Inhibitor
Algorithm by Dr. Waseem Ahmed @Waseem_AhmedMD
#Ulcerative #Colitis #UC #Persistent #5ASA #Refractory #Treatment #Management #Algorithm
