Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓ • MCGN type 1 C3 ↓ C4 ↓↓ • Cryo C3 ↓ C4 ↓↓ • Hereditary angiooedema C3 C4 ↓↓ • C3GN C3 ↓ C4 → • Infection eg SBE C3 ↓ C4 ↓ or → • PIGN C3 ↓ C4 → • Atheroemboli C3 ↓ C4 → • HUS C3 ↓ C4 → • Severe sepsis C3 ↓ C4 ↓ or → • Malnutrition C3 ↓ C4 → • Hepatic failure C3 ↓ C4 ↓ - Dr. John Booth @ThePeanutKidney #Complement #Levels #C3 #C4 #differential #diagnosis #c4 #c3
