IBD - Assessment of Lack of Response (sLOR) - Differential Diagnosis
Non-inflammatory mechanisms:
• IBS
• Fibrostenotic strictures
• Malignancy
• Other (bile salt diarrhea, SIBO, lactose)
Inflammatory mechanisms, Non-IBD related:
• Infection
• Ischaemic
Inflammatory mechanisms, IBD-related:
• Immunogenicity failure: immune drug clearance - ADA
• PK failure: non-immune drug clearance
- Inflammatory burden
- Low albumin level
- Fecal loss
- Non-adherence
• PD failure
Dr. Jean Donet @JeanDonet
#IBD #sLOR #LossOfResponse #Differential #Diagnosis #Causes #Inflammatory #BowelDisease
