Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction and Impaired Production - Flow cytometry, Bone marrow Biopsy and Screen for HLH 1. PNH 2. Hematological Malignancies 3. Autoimmune condition 4. HLH syndrome 5. Drugs Nutritional 1. Eating disorders 2. Bariatric surgery 3. Malabsorption 4. Inadequate intake 5. Alcoholism Bone Marrow Hypoplasia - Cytogenetics and FISH • Acquired Aplastic Anemia • Hypoplastic MDS • Congenital bone marrow failure syndrome Non-Nutritional - Malignancy 1. Primary hematological Malignancy 2. Metastatic Disease (myelophthisis) #Pancytopenia #Workup #Differential #Diagnosis #Algorithm #Hematology
