Mechanisms of nephron damage in cardiorenal syndrome • Increased renal interstitial pressure • Hypoperfusion • Reduced renal blood flow • Tubular damage • Tubular collapse and hypertrophy • Sodium avidity • Increased AVP and Aldosterone activities • Diuretic resistance • ↑ Na+ reabsorption • Adenosine release • ↓ Cl- concentration • Increased CVP • Venous congestion • Reduced compliance #cardiorenal #syndrome #Mechanisms #pathophysiology #nephrology
