Retinoblastoma - MRI
• Most common intra-ocular neoplasm in children.
• Clinical Presentation: leukocoria (loss of red light reflex).
• Epidemiology: most cases are diagnosed within the first 4 years of life.
• Bilateral tumours (30-40%) almost always have a germline mutation.
• Unilateral tumours (60-70%) are caused by a germline mutation in 15% of cases.
• With germline mutations there is a risk of developing trilateral retinoblastoma, involving both globes and the pineal gland (pineoblastoma).
• Metastases:
- Direct spread into the orbit;
- Leptomeningeal disease;
- Haematogeneous metastases to bone, bone marrow and liver;
- Rarely involvement of regional lymph nodes.
- Dr. Amar Chotai @DrAmarChotai
#Retinoblastoma #MRI #diagnosis #neuroradiology #pediatrics #radiology
