Diarrhea Workup and Management Algorithm in Transplant Patients First Tier Microbiologic-Testing: 1. C. difficile PCR (Stool) 2. CMV qPCR (Serum/Blood) 3. Norovirus PCR (Stool) 4. Bacterial culture (Stool) * If available consider multiplex PCR for Broad range of enteric pathogens First Tier Microbiologic-Testing: 1. Ova and Parasite evaluation (stool) 2. Giardia and Cryptosporidium EIA (Stool) 3. Breath test for bacterial overgrowth If above testing negative and diarrhea persists: 1. Adjust IS medications *Reduce dose of change to different agent 2. Colonoscopy +/- EGD *Especially if concern for PTLD, GVHD or IBD 3. Empiric therapy with probiotic or anti-motility agents 4. Evaluate for malabsorption #Diarrhea #Workup #Management #Algorithm #Transplant #diagnosis #differential
