Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
• AST/ALT elevation > Alk phos
• ALT more specific for hepatic pathology (low level of expression in skeletal muscle and kidney)
Is it a Hepatocellular or Cholestatic Liver Injury?
• R value = (ALT + ULN ALT) / (alkaline phosphatase + ULN alkaline phosphatase)
R ≥ 5 = Hepatocellular injury
R ≤ 2 = Cholestatic injury
- Ann Marie Kumfer @AnnKumfer
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