Causes of Pseudocellulitis - Differential Diagnosis Framework for Cellulitis Mimics Cellulitis: Deep skin and subcutaneous fat infection Pseudo Cellulitis: • Uncomplicated non-necrotizing inflammation of the dermis and hypodermis from a non-infectious etiology. However, many non-infectious entities can mimic cellulitis and must be differentiated. • Imperative to diagnose to avoid unnecessary antibiotics and avoid allergic reactions, C. diff, change in host flora, and substantial health care spending. • Early consult by dermatologists represents a cost-effective intervention and reduces inappropriate antibiotic use and hospitalization. • Tetrad of key physical findings: - Rubor, Dolor, Calor, and Rumor are non-specific markers of inflammation. • Misdiagnosis as high as 28% in US hospitals. Inflammatory Causes of Pseudocellulitis: • Drug reaction • Contact dermatitis • Angioedema • Sweet syndrome • Gout • Acute bursitis • Erythema nodosum • Pyoderma gangrenosum • Sarcoidosis • Eosinophilic cellulitis • Panniculitis • Polyarthritis nodosum • Erythema migrans Vascular Causes of Pseudocellulitis: • Venous stasis • Stasis dermatitis • Lymphedema • DVT • Superficial thrombophlebitis • Hematoma • Erythromelalgia • Calciphylaxis • Superficial migratory thrombophlebitis Neoplastic Causes of Pseudocellulitis: • Lymphoma • Leukemia • Carcinoid erysipelas • Inflammatory carcinoma - Lung, Pancreatic, GI • Paraneoplastic Miscellaneous Causes of Pseudocellulitis: • Insect bites/stings • Foreign body implant • Coma bullae • Compartment syndrome • IV infiltration By Dr. Ravi Singh @rav7ks #Pseudocellulitis #Differential #Diagnosis #cellulitis #mimics #mimickers #Causes #dermatology #skin
