Vasopressor Receptor Activities alpha - beta1 - beta2 - DA - Vasopressin Dopamine (ug/kg/min) Epinephrine

Vasopressors and Inotropes - Comparison Table Activity: Alpha-1, Beta-1, Dopamine, SVR, HR, CO, BP Phenylephrine Vasopressin Norepinephrine Epinephrine Dopamine Dobutamine Isoproterenol Milrinone - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/ #Vasopressors #Inotropes #comparison #table #pharmacology #criticalcare

Vasopressors and Inotropes - Pharmacology Summary Vasopressors Phenylephrine (alpha-1) • Increases BP, SVR • Risk of reflex bradycardia due to increased MAP Norepinephrine (Levophed, alpha-1 / beta1, beta1 > beta2) • Increases BP, SVR, CO • Preferred first agent in shock Epinephrine (beta1 > beta2 / alpha1) • Increases HR, SVR, CO, BP • Higher doses cause more alpha-effect • 1st agent in anaphylaxis, 2nd line in septic shock Vasopressin (V1, V2) • Increases BP, SVR, not inotropic/chronotropic • V1, vessel constriction • V2 antidiuretic effect at kidney Dopamine (D1 > beta1 > alpha1) • Dose dependent receptor activation • D1 (1-2 mcg/kg/min): renal artery dilation • beta /mild alpha (5-10 mcg/kg/min): increases HR, contractility, CO • a (>10 mcg/kg/min): vasoconstriction, SVR Inotropes Dobutamine (beta1 > beta2 > alpha1) • Increases CO, less of a BP effect Milrinone (PDE3) • Phosphodiesterase inhibitor > increases cAMP/cGMP • Causes vasodilation and increased contractility - Rebecca Steinberg @RebeccaSteinb17 #Vasopressors #Inotropes #Pharmacology #Summary #management #medications

REBEL Review 4 & 5: Paralytic & Vasopressor Dosing Paralytic Agents: - Succinylcholine (Depolarizing Agent) - Vecuronium - Rocuronium Vasopressors: - Norepinephrine - Epinephrine - Dopamine - Phenylephrine - Vasopressin #vasopressors #paralytics #agents #RSI #RapidSequenceIntubation #resuscitation #table #criticalcare #pharmacology #dosing #medications #Comparison

Clinician's Pocket Guide to Vasopressors - Receptor Profiles and Hemodynamic Parameters • Systemic Vascular Resistance - Circulatory pressure • Inotropy - Altered force of myocardial contractions • Chornotropy - Changes in the heart rate • MAP - Mean Arterial Pressure; indicates end organ perfusion (2*(Diastolic BP) + (Systolic BP)) / 3 • Cardiac Output - volume of blood pumped from each ventricle/min Norepinephrine Phenylephrine Epinephrine Dopamine Vasopressin #Vasopressors #Pharmacology #Summary #cheatsheet #management #comparison #table #receptors #inotropes

Vasopressors Table Rough properties by Target Receptor, Heart Rate/Inotropy, Systemic Vascular Resistance, Cardiac Output, Blood Pressure, Pulmonary Vascular Resistance, Main Uses, Peripheral Safety Inodilators: - Dobutamine 2-20 mcg/kg/min - Milrinone 0.375-0.75 mcg/kg/min - Isoproterenol 2-10 mcg/min Pure Vasopressors: - Vasopressin 0.01-0.06 u/min - Phenylephrine 40-180 mcg/min Inopressors - Norepinephrine 0-40 mcg/min - Epinephrine 0-20 mcg/min - Dopamine, low 1-4 mcg/kg/min - Dopamine, medium 4-10 mcg/kg/min - Dopamine, high 10-20 mcg/kg/min Internet Book of Critical Care @iBookCC #Vasopressors #Properties #Table #Pharmacology #Effect #Management #Comparison #Inotropes

Simplified Vasopressors and Inotropes Comparison Chart MAP = CO x SVR Dobutamine - Norepinephrine - Epinephrine - Phenylephrine - Vasopressin When in doubt choose norepinephrine! Dr. Skyler Lentz @SkylerLentz #Vasopressors #Inotropes #comparison #table #criticalcare #pharmacology

Receptor actions of sympathomimetic and dopaminergic agents. Adrenaline (epinephrine) Noradrenaline (norepinephrine) Isoprenaline Dopamine Dopexamine Dobutamine #Pharmacology #Vasopressors #Receptors #Targets #Specificity #Dopamine #Comparison #Inotropes

Vasoactive Agents - Receptor Profiles Adrenergic Profile: α → β phenylephrine, norepinephrine, dopamine, epinephrine, dobutamine, isoproterenol - Dr. Rishi Kumar @rishikumarmd #Vasoactive #Agents #Receptors #Profiles #alpha #beta #vasopressor #inopressor #adrenergic #comparison

Summary of the therapeutic uses of adrenergic agonists Table of Catecholamine Pressors, Non-Catecholamines, Alpha and Beta Receptor Targets and Therapeutic Uses #Pharmacology #Vasopressors #NonCatecholamines #Receptors #Targets #Specificity #Alpha #Beta #Table #Comparison

Vasopressors - Charted by Vasoconstriction, Vasodilation, and Inotropy - Dobutamine - Milrinone - Vasopressin - Midodrine - Phenylephrine - Norepinephrine - Epinephrine - Dopamine - Nitroprusside #Vasopressors #Vasoconstriction #Vasodilation #Inotropy #Comparison #Chart #Pharmacology #Visual #Inotropes #Guide #Summary