Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment Stop offending agents: • List as allergies in EMR • Don't re-challenge! Steroids for severe systemic dz: • Methylprednisolone 0.5 - 1.5 mg/kg with slow taper over 8+ weeks • Alternatives: cyclosporine, IVIG etc • Skin: topical steroid +/- oral antihistamine for pruritis Continued monitoring: • CBC with Diff, manual absolute Eos count daily • LFTs daily • Cr daily • Watch for mucosal involvement -> alternate dx - BWH Medicine Chiefs @BrighamChiefs #DRESS #Syndrome #Treatment #Management #dermatology
