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Signaling Mechanism of PD-1 and PD-L1 and Inhibition of PD-1 Signaling in Microsatellite-Instability–High Cancers. MHC1 denotes major histocompatibility complex 1 #Pathophysiology #Honc #Pharm #PD1 #PDL1 #Inhibition #MicrosatelliteInstability #NEJM