Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU (cancer), GYN (cancer, menses), Epistaxis, Surgery, Hemodialysis • Iron loss: Intravascular hemolysis, (PNH, sickle-cell, prosthatic valve), Intensive athletic training, Pulmonary hemosiderosis • Inadequate intake for needs: Infancy, Adolescence, Pregnancy, Lactation, Low iron diet MALABSORPTION • Decreased ferrous iron from achlorhydria: PPI or H2-blocker, H.pylori, Atrophic gastritis, Gastrectomy • Increased hepcidin: Chronic kidney disease, Heart failure, Cancer/Waldenstroms, Rheumatoid arthritis and other chronic inflammatory conditions, Obesity, Polycythemia vera • Competitive inhibition with DMT1: Zinc, Manganese, Calcium, Cadmium, Lead • Structural problem (loss of sites of absorption): Celiac disease, Bypass surgery, Bacterila overgrowth, Hookworm, whipworm - Dr. Tony Breu @tony_breu #Iron #Deficiency #Differential #Diagnosis #Causes #Fe #algorithm
