Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
- TTP/HUS, HELLP ... Syndrome and Acute ... child * Severe cases ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Three syndromes ... child * Severe cases ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison ... #Table
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 β€’ Acute infection
 β€’ Solid organ
Causes of Thrombocytosis ... Thrombocytosis): β€’ Acute infection ... Post-splenectomy Primary ... Myelodysplastic syndrome ... #hematology #secondary
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 β€’ Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Causes of Antibiotic ... NMS, serotonin syndrome ... Soon: Can take 48 hrs ... Immunocompromise Treatment ... to Treatment: Drug
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... There are primary ... and secondary TMA ... cancer, transplant, infection ... , pregnancy, & malignant
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
Without treatment ... soles in 50% of cases ... and nephrotic syndrome ... to asymptomatic infection ... roots, causing a syndrome
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 β€’ Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... (HUS) β€’ Other ... usually IgM) (e.g. primary
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... infiltration: malignancy, infection ... Microangiopathy: DIC, TTP, HUS ... antiphospholipid syndrome ... - Pregnancy: HELLP
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... diagnosed annually in US ... risk-stratification β€’ Risks: infection ... #hematology #oncology
Syphilis - Clinical Manifestations and Treatment

1) Primary Syphilis
 β€’ Direct lesion contact during sex is responsible
1) Primary Syphilis ... responsible for most cases ... . 2) Secondary ... Albuminuria, nephrotic syndrome ... β€’ Primary, secondary