Mithu Maheswaranathan, MD @MithuRheum
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Rheumatologist at Duke University Creator of Rheum OnePagers ➡ RheumOnePagers.com Twitter: @MithuRheum ➡ https://twitter.com/MithuRheum
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diagnosis rheumatology ana antibodies antinuclear differential patterns associations autoantibodies management nephrology renal sclerosis signs symptoms table testing workup
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
(Scleroderma) ... (SSc): • Limited ... distal to elbows/wrists ... renal crisis (SRC ... #SSc #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Juvenile Idiopathic Arthritis ... Sjogren's Syndrome (SS ... (SSc) • Nucleolar ... sclerosis/scleroderma ... sclerosis/scleroderma
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
) and Anti-La (SSB ... Anti-JO-1, Others: SRP ... TIF1y, MDA5 • Scleroderma ... (Systemic Sclerosis ... , SSc): Anti-centromere
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Juvenile Idiopathic Arthritis ... Sjogren's Syndrome (SS ... (SSc) • Nucleolar ... ), Rheumatoid Arthritis ... Juvenile Idiopathic Arthritis
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Scleroderma Renal ... Crisis (SRC) ... Renal Crisis: ... onion-skinning" of arteries ... MithuRheum #SRC
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