The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs psychiatry behavioraldisorder mooddisorders vasculitis affectivedisorder amsuicide arteritis attentiondeficithyperactivedisorder benign bipolar bpd bph cd cecs chronicexertional compartmentsyndrome conduct disease
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... Clinical Findings Symptoms ... included in DSM 5 criteria ... MajorDepressiveDisorder #Depression ... MoodDisorders #Diagnosis #Pathophysiology
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings - For diagnosis, must have either 26
have either 26 symptoms ... 2 settings - Symptoms ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... signs #psychiatry #criteria
Borderline Personality Disorder: Pathogenesis and Clinical Findings Behavioral Traits: • Unstable Relationships - Alternating extremes of idealization
Borderline Personality ... the above with symptoms ... impairment #BPD #Borderline ... Diagnosis #Psychiatry #Criteria ... #Signs #Symptoms
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
inflammatory cytokine expression ... old; F>M Signs/Symptoms ... Temporal #Arteritis #Pathophysiology ... Diagnosis #Signs #Symptoms
Schizophrenia: Pathogenesis and Symptoms Increased dopaminergic transmission in mesolimbic projection -> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... cause the Positive Symptoms ... Diminished emotional expression ... Schizophrenia #pathophysiology ... #diagnosis #symptoms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
pathway -> Incr gene expression ... lipolysis Signs/Symptoms ... endocrinology #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Upregulate gene expression ... #Osteoporosis #pathophysiology ... #signs #symptoms
Pediatric Parasomnias and Nightmares: Pathogenesis and clinical findings Parasomnias - Micro-arousal episodes during SWS -> Intense activation of
Fearful facial expression ... Pediatrics #Peds #pathophysiology ... #symptoms #pharmacology
Xeropthalmia: Pathogenesis and Ocular Manifestations Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
& Decr surface expression ... #Xeropthalmia #pathophysiology ... diagnosis #signs #symptoms
Bipolar Disorder: Pathogenesis and Clinical Findings • Disruption of emotional homeostasis • Oscillation between mood states
maintain this state Depressive ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms
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