The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Selective Serotonin ... Dizziness - Nausea ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis ... #Signs #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine ... , Vomiting Serotonin ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis ... #Signs #Symptoms
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
spinal cord - Signs ... and Symptoms ... #Myelopathy #diagnosis ... #signs #symptoms ... #msk
Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings

Psychological Hypothesis
 • Cognitive behavioral model: Emotional disturbance arising from
Hypotheses • Serotonin ... of postsynaptic serotonin ... PersonalityDisorder #Diagnosis ... #Psychiatry #Signs ... #Symptoms
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
test • + Tinel sign ... • + Froment's sign ... + Wartenbergs sign ... CubitalTunnel #Syndrome #Diagnosis ... #symptoms #msk
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... and Symptoms ... Radiculopathy #MSK ... #diagnosis #signs ... #symptoms #pathophysiology
Third Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) Example: Aripiprazole
Dopamine D2 Receptor Partial Agonist
 • Binds
under-stimulating receptors Serotonin ... ThirdGeneration #Mechanisms #SideEffects ... #pharmacology #diagnosis ... #psychiatry
Second Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
the brain • Serotonin ... the brain • Serotonin ... SecondGeneration #Mechanisms #SideEffects ... #pharmacology #diagnosis ... #psychiatry
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
is thought to cause ... is thought to cause ... pathophysiology #diagnosis ... #symptoms #signs ... #psychiatry #positive
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
XR — scotty dog sign ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology ... #signs #symptoms