The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms msk complications sle erythematosus systemic acute avascularnecrosis comparison degenerative differential disruptors extraarticular femur fracture fractures gastrointestinal healing
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... Myopathy (Also caused ... #Systemic #Lupus ... signs #symptoms #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Gastrointestinal Manifestations ... #Systemic #Lupus ... signs #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... hair follicles -> causes ... Mucocutaneous #Manifestations ... pathophysiology #diagnosis
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
Viral replication causes ... swelling - GI Manifestations ... Pathophysiology #Diagnosis
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Fractures #msk #orthopedics ... #diagnosis #differential ... #causes #pathophysiology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... inflammation tends to cause ... signs #symptoms #diagnosis
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Rheumatoid arthritis, Lupus ... Extra-articular manifestations ... JointDisease #JointPain #Diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Injury #Syndromes #diagnosis ... symptoms #msk #orthopedics ... #neurology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
SUI or UUI not caused ... Signs #Symptoms #Urology ... #Diagnosis
Varicocele: Pathogenesis and clinical findings Primary: - Anatomically: the left spermatic vein drains into the left renal
retroperitoneal masses ... Signs #Symptoms #Urology ... #Diagnosis
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