The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
chromosome 21) Signs ... Executive planning dysfunction ... concentration • Motor dysfunction ... pathophysiology #geriatrics ... #diagnosis #signs
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Upper Extremity Dysfunction ... deficiencies -> Sphincter dysfunction ... weakness and #Acute ... pathophysiology #signs
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology ... #peds #pediatrics
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... pathophysiology #peds ... #pediatrics
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children)
Upper Respiratory Tract Infection: 
 - Bacterial: Streptococcus
Acute Otitis Media ... diagnosis #symptoms #signs ... #peds #pediatrics
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Signs / Symptoms ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Takayasu’s Arteritis: Pathogenesis and clinical findings

 - Fatigue, weight loss, low grade fever, arthralgias
 - Incr
aneurysms - Visual Dysfunction ... , Incr risk of Acute ... Vasculitis #Diagnosis #Signs