The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Penicillin-induced drug reaction ... Stevens-Johnson Syndrome ... Dermatitis (ie. reaction ... #Allergic #Reactions ... Classification #Diagnosis
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... Stevens-Johnson Syndrome
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
reaction • Type ... reaction • Type ... An allergic reaction ... #Allergic #Reactions ... Classification #Diagnosis
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... reaction -> Benign ... mediated cytotoxic reaction ... Stevens-Johnson Syndrome
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained
Early Follicular Phase (Days 0-5)
 • Granulosa cells
Polycystic Ovarian Syndrome ... MenstrualCycle #OvarianCycle ... FollicularPhase #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Carpal Tunnel Syndrome ... Overproduction #diagnosis ... signs #symptoms #endocrinology