The Calgary Guide to Understanding Disease @TheCalgaryGuide
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allergy hypersensitivityreaction c5c9deficiency immunity inflammation inflammatory type1 typei xlinked
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... dead tissue • Complement ... Recruitment • Humoral ... #Inflammation #pathophysiology ... #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Type II Hypersensitivity ... activates the complement ... cascade, which ... #Allergy #Immunology ... #pathophysiology
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis: Pathogenesis ... Anaphylaxis is ... a Type 1 hypersensitivity ... #pathophysiology ... #immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
X-Linked Agammaglobulinemia ... deficiency in adaptive humoral ... common antigens #Agammaglobulinemia ... #XLinked #pathophysiology ... #immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... cascade -> MAC ... #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... activation • Complement ... repeat exposure #Humoral ... #Immunity #pathophysiology ... #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Type I Hypersensitivity ... conjunctivitis • Anaphylaxis ... #TypeI #Type1 ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
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