The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology signs symptoms acute manifestations otitismedia urology anaphylaxis ankylosingspondylitis benign bph bulimianervosa cholesteatoma extraarticular incontinence lupus middleear mixed mucocutaneous ophthalmology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Signs / Symptoms / Complications ... pathophysiology #immunology ... #diagnosis #signs
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Tissue injury and inflammation ... pathophysiology #diagnosis ... signs #symptoms #complications
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... pathophysiology #diagnosis ... signs #symptoms #complications
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Otitis Media: Complications ... Infection and inflammation ... Signs/Symptoms/Complications ... • Intracranial complications ... symptoms #signs #diagnosis
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... reflex) • Orbital inflammation ... ophthalmology #diagnosis
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... resolve by 72 hours Complications ... pathophysiology #diagnosis
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic Hyperplasia ... FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... Benign #Prostatic #Hyperplasia ... Signs #Symptoms #Diagnosis
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
(neurogenic), inflammation ... Incr PVR if a complication ... Symptoms #Urology #Diagnosis
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis: Complications ... • Ocular - Inflammation ... WBCs activity -> inflammation ... pathophysiology #diagnosis ... signs #symptoms #Complications
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Manifestations • Ocular - Inflammation ... • Cardiac - Inflammation ... - Ligamentous inflammation ... Manifestations #Complications ... pathophysiology #diagnosis
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