The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology allergy c5c9deficiency cascade inflammatory type2 type4 typeiv
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... destruction), promote inflammation ... activation of complement ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... TypeIV #Type4 #HypersensitivityReaction ... #Allergy #Immunology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... #Type2 #Type2 #HypersensitivityReaction ... #Allergy #Immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... • Inflammation ... pathophysiology #immunology
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