The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology complications diagnosis hypersensitivityreaction signs symptoms ankylosingspondylitis benign bph cascade extraarticular hyperplasia lower luti manifestations prostate type1 type4 typei typeiv
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... release the pro-inflammatory ... secretion • Inflammatory ... #Immunology #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... Initial exposure to allergen ... cells or CTLs -> Inflammation ... #Immunology #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic ... FGF-related proteins) Inflammation ... Inflammation: Incr ... activation of inflammatory ... Urgency, nocturia, incontinence
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacterial toxins and inflammation ... in a systemic inflammatory ... urethra travel to prostate ... via prostatic ducts
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... • Cardiac - Inflammation ... - Ligamentous inflammation ... Bladder and bowel incontinence
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