The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms adhesivecapsulitis benign bph c5c9deficiency comparison complement degenerative disruptors fracture frozenshoulder healing hyperplasia jointdisease jointpain orthopedics prostate
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... stop, but post-inflammatory ... #staging #msk
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
-> Complement cascade ... altered mental status ... • Inflammation ... pathophysiology #immunology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Lots of fluid, takes ... Swollen Joints • Inflammation ... mild synovial inflammation ... Comparison #Versus #MSK
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
alterations (result of aging ... FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... UTIs & bladder stones
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
this process) Inflammatory ... of hematoma -> Inflammatory ... NSAlDs - Block the inflammatory ... #Orthopedics #msk ... #Staging #pathophysiology
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