The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs adhesivecapsulitis benign bph c5c9deficiency centralretinalartery comparison complement crao degenerative frozenshoulder hyperplasia jointdisease jointpain mastoiditis occlusion ophthalmology otology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... pathophysiology #diagnosis #symptoms ... #staging #msk
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... mucosa leads to inflammation ... are connected) Stage ... : Extension of inflammatory ... pathophysiology #signs #symptoms
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
-> Complement cascade ... altered mental status ... • Inflammation ... pathophysiology #immunology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Lots of fluid, takes ... Swollen Joints • Inflammation ... mild synovial inflammation ... Comparison #Versus #MSK
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... hypercoagulable state ... Hypercoagulable state ... viscosity and inflammation ... diagnosis #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... UTIs & bladder stones ... Urology #Signs #Symptoms
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