The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs complications vasculitis msk ophthalmology temporal acute cellulitis disease extraarticular giantcell lupus manifestations otitismedia pediatrics peds psoriaticarthritis ra rheumatoidarthritis
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... mutation) that alter inflammatory ... old; F>M Signs/Symptoms ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Reactive Arthritis ... • Inflammation ... Effusions • Inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... pathophysiology #signs #symptoms ... #diagnosis #ExtraArticular
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Signs / Symptoms ... pathophysiology #immunology ... #diagnosis #signs ... #symptoms
Psoriatic Arthritis: Pathogenesis and Clinical findings In tendons and connective tissues: • Enthesitis - Pain/tenderness over
Psoriatic Arthritis ... • Dactylitis - Inflammation ... Arthritis of DIP ... pathophysiology #diagnosis ... #signs #symptoms
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Cell (Temporal) Arteritis ... Complications Signs/Symptoms ... Stroke or TIA-like symptoms ... GiantCell #Temporal #Arteritis ... #diagnosis #Vasculitis
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... in Rheumatoid arthritis ... mild synovial inflammation ... JointDisease #JointPain #Diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... : Extension of inflammatory ... pathophysiology #signs #symptoms ... #diagnosis #otology
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