The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis complications extraarticular manifestations psoriaticarthritis rheumatoidarthritis urology adhesivecapsulitis ankylosingspondylitis benign centralretinalartery crao frozenshoulder hyperplasia incontinence lupus mastoiditis mixed mucocutaneous occlusion
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis (RA ... effusion on CXR • RA ... RheumatoidArthritis #RA ... #pathophysiology ... #signs #symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... Extra-articular signs ... #pathophysiology ... #signs #symptoms
Psoriatic Arthritis: Pathogenesis and Clinical findings In tendons and connective tissues: • Enthesitis - Pain/tenderness over
• Dactylitis - Inflammation ... polyarthritis (like RA ... PsoriaticArthritis #pathophysiology ... #diagnosis #signs ... #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... -> Incr local inflammation ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
as post-inflammatory ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages ... #staging #msk
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... activation of inflammatory ... bladder stones #BPH ... Hyperplasia #Prostate #Pathophysiology ... #Urology #Signs
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
tumour, stone, BPH ... (neurogenic), inflammation ... Incontinence #Mixed #Pathophysiology ... #Signs #Symptoms
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
• Ocular - Inflammation ... Valvular disease - Inflammatory ... PsoriaticArthritis #pathophysiology ... #diagnosis #signs ... #symptoms #Complications
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis #signs ... #symptoms
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