The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs complications manifestations msk peds adhesivecapsulitis ankylosingspondylitis benign bph cascade centralretinalartery childhood comparison degenerative extraarticular frozenshoulder hyperplasia immunization jointdisease
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... cytokines -> localized inflammatory ... Subacute cutaneous lupus ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... due to upstream CRAO ... #pathophysiology ... diagnosis #signs #symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... mild synovial inflammation ... JointPain #Diagnosis #pathophysiology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... #OtitisMedia #pathophysiology ... #diagnosis #symptoms ... #signs #peds #pediatrics
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... Hyperplasia #Prostate #Pathophysiology ... Urology #Signs #Symptoms
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Diphtheria Toxin -> URT inflammation ... hemorrhagic rash; symptoms ... Metabolites -> Inflammation ... Immunization #peds #pediatrics ... #pathophysiology
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