The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology allergy hypersensitivityreaction c5c9deficiency cascade humoral immunity inflammation inflammatory lupus oncogenesis oncology sle systemic type2 type3 typeiii
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections ... Oncogenesis Note: A retrovirus ... Examples of retrovirus-associated ... /leukemia) #Retroviral ... pathophysiology #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... pathophysiology #immunology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Systemic Lupus • Erythematosus ... HypersensitivityReaction #Allergy #Immunology
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... HLA-DR3 genes, complement ... self-antigens, activating complement ... Systemic #Lupus #Erythematosus
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... C7, C8, C9 -> Complement ... pathophysiology #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... - Activate Complement ... : Abs activate complement ... pathophysiology #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy #Immunology
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