The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology agammaglobulinemia c5c9deficiency cascade inflammation inflammatory xlinked
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Continued Innate Immunity ... dead tissue • Complement ... Recruitment • Humoral ... activation of complement ... pathophysiology #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... contribute to immunity ... repeat exposure #Humoral ... #Immunity #pathophysiology ... #immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... proteins leak out ... pathophysiology #immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
deficiency in adaptive humoral ... immunity Signs ... pathophysiology #immunology
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