The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Equina Syndrome Causes ... / Symptoms / Complications ... pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
A good mnemonic ... Signs / Symptoms ... / Complications ... #Macroadenoma #SideEffects ... endocrinology #mnemonic
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
with keratotic scaling ... hair follicles -> causes ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
) • Fracture disrupts ... Fluoroquinolones - Causes ... #Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
a stroke that caused ... pathophysiology #diagnosis ... #symptoms #signs ... #stages #staging ... #msk
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: Complications ... bone formation MSK ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Obsessive-Compulsive Personality Disorder (OCPD): Pathogenesis and Clinical Findings
 • Miserly - Lack of generosity when it
themselves; hoard in case ... and efficiency, starting ... PersonalityDisorder #Diagnosis ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic