The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Inflammatory and Degenerative ... > Stiffness is short-lived ... #Comparison #Versus ... #MSK #JointDisease ... JointPain #Diagnosis #pathophysiology
Isolated Anterior Cruciate Ligament (ACL) Injury: Pathogenesis and clinical findings
 • Feeling a "pop"
 • Acute
Drawer test #AnteriorCruciateLigament ... #ACL #Injury #MSK ... #Sports #pathophysiology
Overuse Tendinopathy: Pathogenesis and clinical findings
 • Intrinsic factors: Age, Body weight, Nutrition, Gender, Anatomical variations,
Overuse Tendinopathy ... factors: Occupation, Sport ... conditions #Overuse ... #Tendinopathy #pathophysiology ... #msk
Age Related Macular Degeneration: Pathogenesis and clinical findings

Photoreceptor atrophy 
-> Extracellular debris (drusen) from RPE atrophy/metabolism
Related Macular Degeneration ... blood vessels leak serous ... - Faded/blind spots ... MacularDegeneration #pathophysiology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Tetanus Toxin -> Spores ... shock • Mumps Virus ... lymph -> Koplik's spots ... hepatocellular necrosis & degeneration ... peds #pediatrics #pathophysiology
Posterior Cruciate Ligament (PCL) Injury: Pathogenesis and Clinical Findings
Classification of PCL Iniuries
 • Partial: Translation <
Some sort of end ... , - Lachman, - Varus ... + Lachman or + Varus ... #PCL #Injury #MSK ... #Sports #pathophysiology