The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Third Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) Example: Aripiprazole
Dopamine D2 Receptor Partial Agonist
 • Binds
Third Generation Antipsychotics ... Antidepressant Effects #AntiPsychotics ... #pharmacology #diagnosis ... #psychiatry
Second Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Second Generation Antipsychotics ... Mechanism unknown #AntiPsychotics ... #pharmacology #diagnosis ... #psychiatry
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
restlessness #AntiPsychotics ... #pharmacology #diagnosis ... #psychiatry
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... pathophysiology #ophthalmology ... #diagnosis #signs
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Retinopathy #Diabetes #ophthalmology ... #diagnosis #complications
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
Anorexia Nervosa: Complications ... mortality rates of all psychiatric ... binge-purge subtype #AnorexiaNervosa ... pathophysiology #diagnosis ... signs #symptoms #psychiatry
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
pathophysiology #ophthalmology ... #diagnosis #signs ... #symptoms #complications
Anorexia Nervosa: Signs and Symptoms
Binge/Purge Subtype - Recurrent (once per week) episodes of binge-eating or purging,
irritability #AnorexiaNervosa ... pathophysiology #diagnosis ... signs #symptoms #psychiatry
Anorexia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: concordance
athletics) #AnorexiaNervosa ... pathophysiology #diagnosis ... signs #symptoms #psychiatry
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
Symptoms related to complications ... pathophysiology #diagnosis ... signs #symptoms #psychiatry