The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Age Related Macular Degeneration: Pathogenesis and clinical findings

Photoreceptor atrophy 
-> Extracellular debris (drusen) from RPE atrophy/metabolism
Age Related Macular ... reduces blood flow ... early disease) #AgeRelated ... MacularDegeneration #pathophysiology ... #ophthalmology
Aqueous Humor Production and Drainage
 • Provides nutrition, removes wastes, and transports neurotransmitters to the avascular
structural integrity of ocular ... Pathway (~60-80 % of flow ... ciliary body -> Flows ... #Pathophysiology ... #ophthalmology
Onchocerciasis “River Blindness”: Pathogenesis and Ocular Manifestations
Vectorial Transmission
-> Onchocerca volvulus, a parasitic helminth, matures in to
Pathogenesis and Ocular ... RiverBlindness #pathophysiology ... #ophthalmology
Orbital Cellulitis: Pathogenesis and Clinical Findings
Definitions:
a. Chemosis: Edema of the bulbar conjunctiva
b. Panopthalmitis: inflammation of all
- Impinges on ocular ... Impaired extra-ocular ... Orbital #Cellulitis #pathophysiology ... #ophthalmology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Abnormal blood flow ... narrowing • Slow ... retinal artery blood flow ... Occlusion #CRAO #pathophysiology ... #ophthalmology
Trachoma: Pathogenesis and clinical findings

 • Environmental Factors -> Bacterial infection is encouraged by poor hygiene
from nasal or ocular ... Trachoma #Chlamydia #pathophysiology ... #ophthalmology
Xeropthalmia: Pathogenesis and Ocular Manifestations

Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
Pathogenesis and Ocular ... #Xeropthalmia #pathophysiology ... #ophthalmology
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings
OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
-> crowding of ocular ... resistance to the flow ... ClosedAngle #Glaucoma #pathophysiology ... #ophthalmology
Periorbital Cellulitis: Pathogenesis and Clinical Findings
Definitions:
a. Dacryoadenitis: infection of the lacrimal glands
b. Conjunctivitis: inflammation of the
normal: - extra-ocular ... Periorbital #Cellulitis #pathophysiology ... #ophthalmology
Retinitis Pigmentosa: Pathogenesis and Ocular Manifestations
 • Inherited mutation of rhodopsin gene -> Mode of inheritance
Pathogenesis and Ocular ... formation • Macular ... atrophy • Cystoid macular ... RetinitisPigmentosa #pathophysiology ... #ophthalmology