The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis hypersensitivityreaction immunology menstrualcycle msk ovariancycle sideeffects 21hydroxylasedeficiency 21ohd allergic anticonvulsants classification comparison definitions diabetes diabeticketoacidosis differential disruptors dka
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... causes development ... of allergen-specific ... Allergic reaction ... Initial exposure to allergen
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... antigens are the cause ... HypersensitivityReaction #Allergy
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
leading to an allergic ... cell surfaces causes ... leading to an allergic ... causes development ... An allergic reaction
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
out of cells may cause ... anion gap until it closes ... Abdominal pain, nausea ... pathophysiology #endocrinology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Fractures #msk #orthopedics ... #differential #causes
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... signs #symptoms #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained Around Day 14, estrogen exerts sudden +++ positive feedback
and release LH causes ... pathophysiology #Ovulation #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
For pituitary masses ... Headaches • Nausea ... #SideEffects #endocrinology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... Systemic effect -> Nausea
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... pathophysiology #genetics #endocrinology
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